(19)

(11)

EP 1 240 358 A1

(12)

(43) Date of publication: 18.09.2002 Bulletin 2002/38 (21) Application number: 00984100.8 (22) Date of filing: 08.12.2000

(51) International Patent Classification (IPC)7: C12Q 1/68, A61K 38/16, A61K 38/17, A61K 38/18, A61K 38/19 (86) International application number: PCT/US0033/389 (87) International publication number: WO 0104/2506 (14.06.2001 Gazette 2001/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.12.1999 US 169979 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: NI, Jian Rockville, MD 20853 (US) GENTZ, Reiner, L. Rockville, MD 20850 (US) RUBEN, Steven, M. Olney, MD 20832 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)