(19)

(11)

EP 1 242 050 A2

(12)

(88) Date of publication A3: 10.05.2002 (43) Date of publication: 25.09.2002 Bulletin 2002/39 (21) Application number: 00990262.8 (22) Date of filing: 21.12.2000

(51) International Patent Classification (IPC)7: A61K 9/127, A61K 31/711, A61K 31/713, A61K 38/00, A61K 38/16, A61K 39/395, A61K 48/00, C07H 21/04, C07K 2/00, C07K 16/00, C12N 15/12, C12N 15/63 (86) International application number: PCT/US0034/663 (87) International publication number: WO 0104/6455 (28.06.2001 Gazette 2001/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.12.1999 US 172991 P (71) Applicant: YALE UNIVERSITY New HavenCT 06520 (US)	(72) Inventors: ALTIERIA,Dario,C.Boyer Cen.for Molec.Med.RM 436B 295 CONGRESS AVENUENew Haven, CT 06536 (US) SESSA,William,C.Boyer Ce.for Molec.Med. RM 436D 295 Congress AvenueNew Haven, CT 06536 (US) (74) Representative: Thomson, Paul Anthony et al Potts, Kerr & Co.15, Hamilton Square BirkenheadMerseyside L41 6BR BirkenheadMerseyside L41 6BR (GB)