(19)
(11) EP 1 242 608 A2

(12)

(88) Date of publication A3:
04.04.2002

(43) Date of publication:
25.09.2002 Bulletin 2002/39

(21) Application number: 00991274.2

(22) Date of filing: 27.12.2000
(51) International Patent Classification (IPC)7C12N 15/86, A61K 48/00, A61P 19/02, A61P 37/00
(86) International application number:
PCT/EP0013/297
(87) International publication number:
WO 0104/8231 (05.07.2001 Gazette 2001/27)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 28.12.1999 US 473018

(71) Applicant: Novartis AG
4056 Basel (CH)

(72) Inventors:
  • LU, Patrick
    Rockville, MD 20855 (US)
  • ENNIST, David, Leonard
    Bethesda, MD 20817 (US)
  • MINA, Mervat
    Germantown, MD 20874 (US)

(74) Representative: Gros, Florent 
Novartis AGCorporate Intellectual Property,Patent & Trademark Department CH
4002 Basel
4002 Basel (CH)

   


(54) METHOD OF ACHIEVING PERSISTENT TRANSGENE EXPRESSION