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EP 1 244 669 A1

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(43) Date of publication: 02.10.2002 Bulletin 2002/40 (21) Application number: 00974973.0 (22) Date of filing: 13.11.2000

(51) International Patent Classification (IPC)7: C07D 487/04, A61K 31/495, A61P 25/28, A61P 25/16, A61P 25/22, A61P 9/04, A61P 1/04, A61P 1/18, A61P 13/12, A61P 9/10 (86) International application number: PCT/JP0008/008 (87) International publication number: WO 0104/0230 (07.06.2001 Gazette 2001/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.12.1999 AU PQ441499 (71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD. Osaka-shiOsaka 541-8514 (JP)

(72) Inventors: AKAHANE, AtsushiFujisawa Pharmaceutical Co., Ltd. Osaka-shiOsaka 541-8514 (JP) KURODA, SatoruFujisawa Pharmaceutical Co., Ltd. Osaka-shiOsaka 541-8514 (JP) ITANI, HiromichiFujisawa Pharmaceutical Co., Ltd. Osaka-shiOsaka 541-8514 (JP) TABUCHI, SeiichiroFujisawa Pharmaceu. Co., Ltd. Osaka-shiOsaka 541-8514 (JP) SATO, YoshiniroFujisawa Pharmaceutical Co., Ltd. Osaka-shiOsaka 541-8514 (JP) MATSUOKA, NobuyaFujisawa Pharmaceutical Co., Ltd. Osaka-shiOsaka 541-8514 (JP) TADA, MihoFujisawa Pharmaceutical Co., Ltd. Osaka-shiOsaka 541-8514 (JP) MATSUOKA, HideakiFujisawa Pharmaceu. Co., Ltd. Osaka-shiOsaka 541-8514 (JP) OKU, TakumaFujisawa Pharmaceutical Co., Ltd. Osaka-shiOsaka 541-8514 (JP) TANAKA, AkiraFujisawa Pharmaceutical Co., Ltd. Osaka-shiOsaka 541-8514 (JP) (74) Representative: Gille Hrabal Struck Neidlein Prop Roos  Patentanwälte,Brucknerstrasse 20 40593 Düsseldorf 40593 Düsseldorf (DE)