(19)

(11)

EP 1 244 683 A1

(12)

(43) Date of publication: 02.10.2002 Bulletin 2002/40 (21) Application number: 00977043.9 (22) Date of filing: 08.11.2000

(51) International Patent Classification (IPC)7: C07H 21/04, C07H 21/02, C07K 5/00, C07K 14/00, C12Q 1/68, C12N 1/21, C12N 15/63, C12N 15/85, C12N 15/86 (86) International application number: PCT/US0030/654 (87) International publication number: WO 0103/4629 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.11.1999 US 164835 P 27.07.2000 US 221142 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: RUBEN, Steven, M. Olney, MD 20832 (US) KOMATSOULIS, George, A. Silver Spring, MD 20901 (US) WEI, Ping Brookeville, MD 20833 (US) FISCELLA, Michele Bethesda, MD 20817 (US) BAKER, Kevin, P. Darnestown, MD 20878 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)