(19)
(11) EP 1 244 783 A1

(12)

(43) Date of publication:
02.10.2002 Bulletin 2002/40

(21) Application number: 00982080.4

(22) Date of filing: 29.11.2000
(51) International Patent Classification (IPC)7C12N 15/12, C07K 14/705, A61K 38/17
(86) International application number:
PCT/US0030/166
(87) International publication number:
WO 0104/2463 (14.06.2001 Gazette 2001/24)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 07.12.1999 US 169412 P
07.12.1999 US 169367 P
07.12.1999 US 169381 P
23.03.2000 US 191430 P

(71) Applicant: ELI LILLY AND COMPANY
Indianapolis, IN 46285 (US)

(72) Inventors:
  • LU, Jirong
    Indianapolis, IN 46326 (US)
  • WITCHER, Derrick, Ryan
    Fishers, IN 46038 (US)

(74) Representative: Pritchard, Judith 
Eli Lilly and Company LimitedLilly Research CentreErl Wood ManorSunninghill Road
Windlesham, Surrey GU20 6PH
Windlesham, Surrey GU20 6PH (GB)

   


(54) IMPROVING STABILITY OF FLINT THROUGH O-LINKED GLYCOSYLATION