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EP 1 244 784 A2

(12)

(88) Date of publication A3: 04.04.2002 (43) Date of publication: 02.10.2002 Bulletin 2002/40 (21) Application number: 00982096.0 (22) Date of filing: 08.11.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/71, A61K 38/18, A61K 39/395, C12N 15/62, C07K 16/28 (86) International application number: PCT/US0030/952 (87) International publication number: WO 0104/9715 (12.07.2001 Gazette 2001/28)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.01.2000 WO PCT/US00/00376 18.02.2000 WO PCT/US00/04342 02.03.2000 WO PCT/US00/05841 30.03.2000 WO PCT/US00/08439 28.07.2000 WO PCT/US00/20710 (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)

(72) Inventors: ASHKENAZI, Avi, J. San Mateo, CA 94402 (US) GODDARD, Audrey San Francisco, CA 94131 (US) GURNEY, Austin, L. Belmont, CA 94002 (US) NAPIER, Mary, A. Hillsborough, CA 94010 (US) WATANABE, Colin, K. Moraga, CA 94556 (US) WOOD, William, I. Hillsborough, CA 94010 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)