(19)

(11)

EP 1 246 843 A1

(12)

(43) Date of publication: 09.10.2002 Bulletin 2002/41 (21) Application number: 01901722.7 (22) Date of filing: 04.01.2001

(51) International Patent Classification (IPC)7: C07K 14/50, A61K 38/18, C07K 16/22, A61K 39/395 (86) International application number: PCT/US0100/238 (87) International publication number: WO 0104/9740 (12.07.2001 Gazette 2001/28)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.01.2000 US 478062 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventor: CONKLIN, Darrell, C. Seattle, WA 98102 (US) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)