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(11)

EP 1 246 847 A2

(12)

(88) Date of publication A3: 08.08.2002 (43) Date of publication: 09.10.2002 Bulletin 2002/41 (21) Application number: 01952456.0 (22) Date of filing: 05.07.2001

(51) International Patent Classification (IPC)7: C07K 14/72, C07H 21/04, C12N 15/63, C12N 5/06, C12N 5/08, C12N 5/10, G01N 33/53, A61K 38/00, C12P 21/02 (86) International application number: PCT/US0121/350 (87) International publication number: WO 0200/2744 (10.01.2002 Gazette 2002/02)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.07.2000 US 610635 (71) Applicant: Synaptic Pharmaceutical Corporation Paramus, NJ 07652 (US)

(72) Inventors: SALON, John, A. Santa Paula, CA 93060 (US) LAZ, Thomas, M. Parlin, NJ 08859 (US) NAGORNY, Raisa Fair Lawn, NJ 07410 (US) WILSON, Amy, E. Woodstock, NY 12498 (US) OGAZALEK, Kristine Rochelle Park, NJ 07662 (US) FORRAY, Carlos Paramus, New Jersey 07652 (US) BLACKBURN, Thomas P Hoboken, NJ 07030 (US) BOROWSKI, Beth Montclair, NJ 07042 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)