(19)

(11)

EP 1 246 915 A2

(12)

(88) Date of publication A3: 07.02.2002 (43) Date of publication: 09.10.2002 Bulletin 2002/41 (21) Application number: 00987208.6 (22) Date of filing: 29.12.2000

(51) International Patent Classification (IPC)7: C12N 15/12, C12P 21/00, C12N 9/24, C12N 15/62, A61K 38/47 (86) International application number: PCT/DK0000/743 (87) International publication number: WO 0104/9830 (12.07.2001 Gazette 2001/28)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.12.1999 DK 189199 02.06.2000 DK 200000865 02.06.2000 DK 200000866 30.06.2000 DK 200001027 (71) Applicant: Maxygen Aps 2970 Hoersholm (DK)	(72) Inventors: OKKELS, Jens, Sigurd DK-2970 Horsholm (DK) JENSEN, Anne, Dam DK-2970 Horsholm (DK) HALKIER, Torben DK-2970 Horsholm (DK) JENSEN, Rikke, Bolding DK-2970 Horsholm (DK) SCHAMBYE, Hans, Thalsgaard DK-2970 Horsholm (DK) (74) Representative: Ryberg, Lise Abildgaard et al Maxygen ApS,Agern Alle 1 2970 Hoersholm 2970 Hoersholm (DK)