(19) |
 |
|
(11) |
EP 1 249 236 A8 |
(12) |
CORRECTED EUROPEAN PATENT APPLICATION |
|
published in accordance with Art. 158(3) EPC |
(48) |
Corrigendum issued on: |
|
02.01.2003 Bulletin 2003/01 |
(43) |
Date of publication: |
|
16.10.2002 Bulletin 2002/42 |
(22) |
Date of filing: 05.11.2001 |
|
(86) |
International application number: |
|
PCT/JP0109/661 |
(87) |
International publication number: |
|
WO 0203/8148 (16.05.2002 Gazette 2002/20) |
|
(84) |
Designated Contracting States: |
|
BE DE ES FR GB IT NL |
(30) |
Priority: |
08.11.2000 JP 2000340459
|
(71) |
Applicant: SODA AROMATIC COMPANY, LIMITED |
|
Tokyo 103-0023 (JP) |
|
(72) |
Inventors: |
|
- ITO, Nobuhiko, Noda Branch, Soda Aromatic Co.,Ltd.
Noda-shi, Chiba 270-0233 (JP)
- TSUJI, Hiroyuki, Soda Aromatic Co., Ltd.
Chuo-ku, Tokyo 103-0023 (JP)
- FUKUDA, Yoshio, Soda Aromatic Co., Ltd.
Chuo-ku, Tokyo 103-0023 (JP)
|
(74) |
Representative: Coleiro, Raymond et al |
|
MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB) |
|
|
|
(54) |
ANTICANCER AGENTS, PERFUMES OR FOODS AND DRINKS CONTAINING OMEGA-HYDROXY FATTY ACIDS |
(57) The present invention relates to drugs and, particularly, to anticancer agents.
More particularly, the present invention relates to an anticancer agents containing,
as an active ingredient, at least one compound selected from the group consisting
of ω-hydroxy fatty acids and salts or esters thereof, hydroxy oxo-fatty acids and
salts or esters thereof, lactones, macrocyclic ketones, and macrocyclic diesters having
specific chemical structures.
With respect to the compounds described above used in the present invention, since
the activities of killing cancer and inhibiting cancer metastasis are significantly
high, the effects of preventing the recurrence of cancer and preventing cancer are
exhibited, the cytotoxicity is significantly low, and a small dose is effective, it
is possible to provide anticancer agents having significantly decreased side effects.
Additionally, use in combination with known antitumor agents can further enhance the
activity of inhibiting cancer metastasis. Among the anticancer agents of the present
invention, ω-hydroxy fatty acids can be easily obtained in high purities by hydrolyzing
lactones which are also the anticancer agents of the present invention.