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(11)

EP 1 250 332 A1

(12)

(43) Date of publication: 23.10.2002 Bulletin 2002/43 (21) Application number: 00986489.3 (22) Date of filing: 15.12.2000

(51) International Patent Classification (IPC)7: C07D 309/04, C07D 295/20, C07D 309/12, C07D 405/12, C07D 417/12, C07C 275/32, C07D 207/12, C07D 295/08, C07D 241/08, C07D 405/04, C07D 235/26, A61K 31/35, A61K 31/40, A61K 31/41, A61K 31/445 (86) International application number: PCT/US0034/229 (87) International publication number: WO 0104/4223 (21.06.2001 Gazette 2001/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.12.1999 US 466608 (71) Applicant: Abbott Laboratories Abbott Park, IL 60064-6050 (US)

(72) Inventors: BASHA, Fatima, Z. Lake Forest, IL 60045 (US) HINMAN, Mira, M. Oak Park, IL 60302 (US) KOPECKA, Hana, A. Vernon Hills, IL 60061 (US) SEARLE, Xenia, B. Grayslake, IL 60030 (US) SOWIN, Thomas, J. Wadsoworth, IL 60083 (US) WODKA, Dariusz Zion, IL 60099 (US) SUROWY, Carol Sturtevant, WI 53177 (US) FALTYNEK, Connie, R. Highland Park, IL 60035 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)