(19)

(11)

EP 1 250 432 A2

(12)

(88) Date of publication A3: 14.03.2002 (43) Date of publication: 23.10.2002 Bulletin 2002/43 (21) Application number: 01905140.8 (22) Date of filing: 26.01.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/10, C07K 14/705, C07K 14/72, C07K 16/28, C12Q 1/68, A61K 38/17, G01N 33/50, G01N 33/53 (86) International application number: PCT/US0102/741 (87) International publication number: WO 0105/5392 (02.08.2001 Gazette 2001/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.01.2000 US 178578 P 25.02.2000 US 185079 P 17.03.2000 US 189999 P (71) Applicant: Incyte Genomics, Inc. Palo Alto, CA 94304 (US)

(72) Inventors: BURFORD, Neil Durham, CT 06422 (US) BAUGHN, Mariah, R. San Leandro, CA 94577 (US) TANG, Y. Tom San Jose, CA 95118 (US) BANDMAN, Olga Mountain View, CA 94043 (US) TRIBOULEY, Catherine, M. San Francisco, CA 94107 (US) DAS, Debopriya Mountain View, CA 94040 (US) POLICKY, Jennifer, L. San Jose, CA 95124 (US) LO, Terence P. Foster City, CA 94404-1941 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)