(19)
(11) EP 1 251 876 A2

(12)

(88) Date of publication A3:
24.01.2002

(43) Date of publication:
30.10.2002 Bulletin 2002/44

(21) Application number: 01903247.3

(22) Date of filing: 22.01.2001
(51) International Patent Classification (IPC)7A61K 49/00
(86) International application number:
PCT/US0102/221
(87) International publication number:
WO 0105/2906 (26.07.2001 Gazette 2001/30)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 22.01.2000 US 177580 P

(71) Applicant: Epix Medical, Inc.
Cambridge, MA 02142-1118 (US)

(72) Inventors:
  • NIVOROZHKIN, Aleksandr
    West Roxbury, MA 02132 (US)
  • MCMURRAY, Thomas, J.
    Winchester, MA 01890 (US)
  • KOLODZIEJ, Andrew
    Winchester, MA 01890 (US)

(74) Representative: VOSSIUS & PARTNER 
Siebertstrasse 4
81675 München
81675 München (DE)

   


(54) MAGNETIC RESONANCE IMAGING USING CONTRAST AGENTS PRODRUGS BIOACTIVATED BY ENZYMATIC CLEAVAGE