(19)

(11)

EP 1 252 187 A2

(12)

(88) Date of publication A3: 07.02.2002 (43) Date of publication: 30.10.2002 Bulletin 2002/44 (21) Application number: 01903325.7 (22) Date of filing: 25.01.2001

(51) International Patent Classification (IPC)7: C07K 14/54 (86) International application number: PCT/US0102/514 (87) International publication number: WO 0105/5211 (02.08.2001 Gazette 2001/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.01.2000 US 178389 P 11.04.2000 US 195962 P (71) Applicant: IMMUNEX CORPORATION SeattleWashington 98101 (US)	(72) Inventor: SIMS, John, E. Seattle, WA 98101 (US) (74) Representative: Cornish, Kristina Victoria Joy et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)