(19)

(11)

EP 1 252 291 A2

(12)

(88) Date of publication A3: 17.01.2002 (43) Date of publication: 30.10.2002 Bulletin 2002/44 (21) Application number: 01942668.3 (22) Date of filing: 16.01.2001

(51) International Patent Classification (IPC)7: C12N 1/21, C12N 15/74 // (C12N1/21, C12R1:20) (86) International application number: PCT/IB0100/143 (87) International publication number: WO 0105/3474 (26.07.2001 Gazette 2001/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 21.01.2000 US 177568 P (71) Applicant: Ibex Pharmaceuticals, Inc. Montreal, Quebec H4P 1P7 (CA)	(72) Inventors: SU, Hongsheng Kirkland, Quebec H9H 5H6 (CA) ZHONGQI, Shao Dollard-des-Ormeaux, Quebec H9B 3E6 (CA) TKALEC, Ana, Lydia St. Leonard, Quebec H1P 2R7 (CA) BLAIN, Françoise LaSalle, Quebec H8P 2Y2 (CA) ZIMMERMAN, Joseph Elm Grove, WI 53122 (US) (74) Representative: Lee, Nicholas John et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)