(19)

(11)

EP 1 252 319 A2

(12)

(88) Date of publication A3: 31.01.2002 (43) Date of publication: 30.10.2002 Bulletin 2002/44 (21) Application number: 01902549.3 (22) Date of filing: 02.02.2001

(51) International Patent Classification (IPC)7: C12N 15/62, C07K 14/00, C12N 15/10 (86) International application number: PCT/GB0100/445 (87) International publication number: WO 0105/7065 (09.08.2001 Gazette 2001/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.02.2000 GB 0002492 04.02.2000 US 180326 P 03.07.2000 GB 0016346 07.08.2000 GB 0019362 (71) Applicant: Domantis Limited London W1N 4AL (GB)	(72) Inventors: RIECHMANN, Lutz Cambridge CB2 2QH (GB) WINTER, Greg Cambridge CB2 2QH (GB) (74) Representative: Maschio, Antonio  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)