(19)

(11)

EP 1 253 930 A2

(12)

(88) Date of publication A3: 14.02.2002 (43) Date of publication: 06.11.2002 Bulletin 2002/45 (21) Application number: 01910587.3 (22) Date of filing: 12.02.2001

(51) International Patent Classification (IPC)7: A61K 38/00, A61K 38/04, A61K 39/00, A61K 45/00, A61K 48/00, C07H 21/04, C07K 2/00, C07K 4/12, C07K 7/06, C12N 5/08, C12N 15/11 (86) International application number: PCT/US0104/539 (87) International publication number: WO 0105/8922 (16.08.2001 Gazette 2001/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.02.2000 US 181966 12.09.2000 US 660252 14.09.2000 US 662505 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94607-5200 (US)	(72) Inventors: ECONOMOU, James, S. Pacific Palisades, CA 90272 (US) BUTTERFIELD, Lisa, H. Long Beach, CA 90807 (US) RIBAS BRUGUERA, Antoni Los Angeles, CA 90024 (US) (74) Representative: W.P. Thompson & Co.  Coopers Building,Church Street Liverpool L1 3AB Liverpool L1 3AB (GB)