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(11)

EP 1 254 102 A1

(12)

(43) Date of publication: 06.11.2002 Bulletin 2002/45 (21) Application number: 01946845.3 (22) Date of filing: 26.01.2001

(51) International Patent Classification (IPC)7: C07C 69/734, A61K 31/216, C07C 59/64, A61K 31/192, A61P 3/04, A61P 3/06, A61P 3/10 (86) International application number: PCT/DK0100/057 (87) International publication number: WO 0105/5086 (02.08.2001 Gazette 2001/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.01.2000 DK 200000137 07.07.2000 DK 200001065 25.10.2000 DK 200001593 (71) Applicant: Novo Nordisk A/S 2880 Bagsvaerd (DK)	(72) Inventors: MOGENSEN, John, Patrick DK-2730 Herlev (DK) SAUERBERG, Per DK-3520 Farum (DK) BURY, Paul, Stanley Burnley, Lancashire BB114PA (GB) JEPPESEN, Lone DK-2830 Virum (DK) PETTERSSON, Ingrid DK-1864 Frederiksberg (DK) (74) Representative: Madsen, Inger Margrethe Schelde et al c/o Novo Nordisk A/S,Patent Department,Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)