(19)

(11)

EP 1 254 149 A1

(12)

(43) Date of publication: 06.11.2002 Bulletin 2002/45 (21) Application number: 01903294.5 (22) Date of filing: 19.01.2001

(51) International Patent Classification (IPC)7: C07H 21/02, C07H 21/04, C12N 1/20, C12N 15/00 (86) International application number: PCT/US0102/386 (87) International publication number: WO 0105/3309 (26.07.2001 Gazette 2001/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.01.2000 US 177251 P (71) Applicants: IDAHO RESEARCH FOUNDATION, INC. Moscow,Idaho 83844-3003 (US) Paszczynski, Andrzej Moscow, ID 83843 (US) Sebat, Jonathan L. Pullman, WA 99163 (US)	(72) Inventors: PASZCZYNSKI, Andrzej Moscow, ID 83843 (US) SEBAT, Jonathan, L. Pullman, WA 99163 (US) LEWIS, Thomas, A. Milton, VT 05468 (US) CRAWFORD, Ronald, L. Moscow, ID 83843 (US) CORTESE, Marc, S. Moscow, ID 83843 (US) (74) Representative: Trueman, Lucy Petra  Barker Brettell,138 Hagley Road,Edgbaston Birmingham B16 9PW Birmingham B16 9PW (GB)