(19)

(11)

EP 1 254 150 A2

(12)

(88) Date of publication A3: 07.02.2002 (43) Date of publication: 06.11.2002 Bulletin 2002/45 (21) Application number: 01914332.0 (22) Date of filing: 17.01.2001

(51) International Patent Classification (IPC)7: C07H 21/02, C07H 21/04, C07K 5/00, C12Q 1/68, C12P 21/06, C12N 1/20, C12N 15/63, C12N 5/00 (86) International application number: PCT/US0101/360 (87) International publication number: WO 0105/5329 (02.08.2001 Gazette 2001/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.01.2000 US 179065 P 04.02.2000 US 180628 P 07.06.2000 US 209467 P 14.09.2000 US 232398 P 17.11.2000 US 249300 P 01.12.2000 US 250160 P 08.12.2000 US 251990 P 08.12.2000 US 251868 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)

(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) BARASH, Steven, C. Rockville, MD 20850 (US) RUBEN, Steven, M. Olney, MD 20832 (US) BRISE, Charles, E. North Potomac, MD 20878 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)