(19)

(11)

EP 1 254 236 A2

(12)

(88) Date of publication A3: 07.02.2002 (43) Date of publication: 06.11.2002 Bulletin 2002/45 (21) Application number: 01907197.6 (22) Date of filing: 08.02.2001

(51) International Patent Classification (IPC)7: C12N 15/52, C12N 9/00, C12N 15/63, C12N 5/10, A01K 67/027, C12P 21/00, C07K 16/40, C12Q 1/68, A61K 38/43, C12Q 1/00, G01N 33/573 (86) International application number: PCT/US0104/423 (87) International publication number: WO 0105/9127 (16.08.2001 Gazette 2001/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.02.2000 US 181856 P 17.02.2000 US 183684 P 25.02.2000 US 185141 P 03.03.2000 US 186818 P 09.03.2000 US 188345 P 17.03.2000 US 189997 P (71) Applicant: Incyte Genomics, Inc. Palo Alto, CA 94304 (US)

(72) Inventors: TANG, Y., Tom San Jose, CA 95118 (US) YUE, Henry Sunnyvale, CA 94087 (US) BAUGHN, Mariah, R. San Leandro, CA 94577 (US) YAO, Monique, G. Mountain View, CA 94043 (US) BANDMAN, Olga Mountain View, CA 94043 (US) AZIMZAI, Yalda Castro Valley, CA 94552 (US) LAL, Preeti Santa Clara, CA 95054 (US) GANDHI, Ameena, R. Menlo Park, CA 94025 (US) RING, Huijun, Z. Los Altos, CA 94022 (US) SHIH, Leo, L. Palo Alto, CA 94303 (US) YANG, Junming San Jose, CA 95129 (US) POLICKY, Jennifer, L. San Jose, CA 95124 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)