(19)

(11)

EP 1 255 568 A2

(12)

(88) Date of publication A3: 25.04.2002 (43) Date of publication: 13.11.2002 Bulletin 2002/46 (21) Application number: 01912804.0 (22) Date of filing: 15.02.2001

(51) International Patent Classification (IPC)7: A61K 47/48, C07K 14/55, C07K 5/10, A61K 38/04, G01N 33/68 (86) International application number: PCT/US0105/225 (87) International publication number: WO 0106/0848 (23.08.2001 Gazette 2001/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.02.2000 US 507140 (71) Applicant: Watson Pharmaceuticals, Inc. Corona, CA 32880-2882 (US)	(72) Inventors: PRAKASH, Ramesh, K. Salt Lake City, UT 84121 (US) ANDERSON, Christopher, G. Salt Lake City, UT 84103 (US) (74) Representative: Roques, Sarah Elizabeth  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)