(19)

(11)

EP 1 255 758 A1

(12)

(43) Date of publication: 13.11.2002 Bulletin 2002/46 (21) Application number: 01904273.8 (22) Date of filing: 09.02.2001

(51) International Patent Classification (IPC)7: C07D 498/04, C07D 513/04, C07D 498/14, A61K 31/554, A61P 35/00 (86) International application number: PCT/IE0100/020 (87) International publication number: WO 0105/8904 (16.08.2001 Gazette 2001/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.02.2000 IE 200120 (71) Applicants: THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Dublin 2 (IE) Universita'di Siena 53100 Siena (IT)	(72) Inventors: WILLIAMS, David, Clive Dalkey,County Dublin (IE) ZISTERER, Daniela, M. Dun Laoghaire,County Dublin (IE) NACCI, Vito I-53100 Siena (IT) CAMPIANI, Giuseppe I-53100 Siena (IT) (74) Representative: Gates, Marie Christina Esther et al c/o Tomkins & Co.5 Dartmouth Road Dublin 6 Dublin 6 (IE)