(19)

(11)

EP 1 255 770 A1

(12)

(43) Date of publication: 13.11.2002 Bulletin 2002/46 (21) Application number: 01906868.3 (22) Date of filing: 01.02.2001

(51) International Patent Classification (IPC)7: C07K 7/08, C07K 7/52, A61K 38/00 (86) International application number: PCT/US0103/293 (87) International publication number: WO 0105/7070 (09.08.2001 Gazette 2001/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 03.02.2000 US 179967 P (71) Applicant: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US)	(72) Inventor: BEDNAREK, Maria Rahway, NJ 07065-0907 (US) (74) Representative: Hiscock, Ian James  European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)