(19)

(11)

EP 1 255 814 A1

(12)

(43) Date of publication: 13.11.2002 Bulletin 2002/46 (21) Application number: 01903412.3 (22) Date of filing: 29.01.2001

(51) International Patent Classification (IPC)7: C12N 5/10, C12N 15/12, C12N 15/63, C12N 15/64, C07K 14/705, C07K 14/71, C07K 14/715, C07K 14/72, C07K 16/18 (86) International application number: PCT/US0102/921 (87) International publication number: WO 0105/5352 (02.08.2001 Gazette 2001/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 31.01.2000 US 494862 (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)	(72) Inventors: ELLIS, Catherine, E. Glassboro, NJ 08028 (US) GATTU, Mahanandeeshwar King of Prussia, PA 19406 (US) SHABON, Usman Collegeville, PA 19426 (US) (74) Representative: Stott, Michael John et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)