(19)

(11)

EP 1 255 849 A2

(12)

(88) Date of publication A3: 28.03.2002 (43) Date of publication: 13.11.2002 Bulletin 2002/46 (21) Application number: 01946888.3 (22) Date of filing: 22.01.2001

(51) International Patent Classification (IPC)7: C12P 21/06, C12N 7/04, A61K 39/12, A61K 39/21, A61K 39/205 (86) International application number: PCT/US0101/989 (87) International publication number: WO 0105/5330 (02.08.2001 Gazette 2001/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.01.2000 US 494262 (71) Applicant: THOMAS JEFFERSON UNIVERSITY Philadelphia,Pennsylvania 19107 (US)	(72) Inventor: SCHNELL, Matthias, J. Harleysville, PA 19438 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)