(19)

(11)

EP 1 257 580 A2

(12)

(88) Date of publication A3: 28.03.2002 (43) Date of publication: 20.11.2002 Bulletin 2002/47 (21) Application number: 01910631.9 (22) Date of filing: 14.02.2001

(51) International Patent Classification (IPC)7: C07K 14/705 (86) International application number: PCT/US0104/644 (87) International publication number: WO 0106/0864 (23.08.2001 Gazette 2001/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.02.2000 US 182325 P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)	(72) Inventors: ROBERDS, Steven, L. Mattawan, MI 49071 (US) KARNOVSKY, Alla, M. Kalamazoo, MI 49009 (US) RUBLE, Cara, L. Paw Paw, MI 49079 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)