(19)

(11)

EP 1 257 654 A1

(12)

(43) Date of publication: 20.11.2002 Bulletin 2002/47 (21) Application number: 01901811.8 (22) Date of filing: 08.01.2001

(51) International Patent Classification (IPC)7: C12N 15/62, C12N 5/10, C07K 14/105, C07K 14/255, C07K 14/14, C07K 19/00, C07K 16/18, C07K 16/10, C12N 15/87, C12N 15/11, G01N 33/53, A61K 39/00, A61K 48/00 (86) International application number: PCT/US0100/426 (87) International publication number: WO 0104/9867 (12.07.2001 Gazette 2001/28)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.01.2000 US 174786 P (71) Applicant: THE RESEARCH AND DEVELOPMENT INSTITUTE, INC Bozeman, MT 59715 (US)	(72) Inventor: PASCUAL, David, W. Bozeman, MT 59718 (US) (74) Representative: Thomson, Paul Anthony  Potts, Kerr & Co.,15, Hamilton Square Birkenhead,Merseyside CH41 6BR Birkenhead,Merseyside CH41 6BR (GB)