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(11)

EP 1 259 482 A2

(12)

(88) Date of publication A3: 16.05.2002 (43) Date of publication: 27.11.2002 Bulletin 2002/48 (21) Application number: 01909377.2 (22) Date of filing: 26.02.2001

(51) International Patent Classification (IPC)7: C07C 323/62, C07C 323/65, C07C 323/09, C07C 323/12, C07C 321/28, C07C 381/04, C07C 381/00, C07C 323/22, A61K 31/22, A61K 31/105, A01N 41/12, A61P 35/00 (86) International application number: PCT/CA0100/234 (87) International publication number: WO 0106/2668 (30.08.2001 Gazette 2001/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.02.2000 US 185189 P 25.02.2000 CA 2299247 (71) Applicant: University Health Network Toronto,Ontario M5G 2M9 (CA)	(72) Inventors: Langler, Richard, Francis Moncton, New Brunswick E1G 1S4 (CA) Baerlocker, Felix, J. Sackville, New Brunswick E4L 3B2 (CA) Penn, Linda, Z.c/o Ontario Cancer Institute Toronto, Ontario M5G 2M9 (CA) (74) Representative: James, Anthony Christopher W.P. et al Carpmaels & Ransford43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)