(19)

(11)

EP 1 259 527 A1

(12)

(43) Date of publication: 27.11.2002 Bulletin 2002/48 (21) Application number: 00978417.4 (22) Date of filing: 08.11.2000

(51) International Patent Classification (IPC)7: C07H 21/04, C07H 21/02, C07K 5/00, C07K 14/00, C12Q 1/68, C12N 1/21, C12N 15/63, C12N 15/85, C12N 15/86 (86) International application number: PCT/US0030/653 (87) International publication number: WO 0103/4628 (17.05.2001 Gazette 2001/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.11.1999 US 164735 P 27.07.2000 US 221193 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: RUBEN, Steven, M. Olney, MD 20832 (US) KOMATSOULIS, George, A. Silver Spring, MD 20901 (US) BIRSE, Charles, E. North Potomac, MD 20878 (US) NI, Jian Germantown,MD 20874 (US) MOORE, Paul, A. Germantown, MD 20874 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)