(19)

(11)

EP 1 259 537 A1

(12)

(43) Date of publication: 27.11.2002 Bulletin 2002/48 (21) Application number: 01912956.8 (22) Date of filing: 23.02.2001

(51) International Patent Classification (IPC)7: C07K 14/00, C12N 5/00, C12N 15/12, C12N 15/63, G01N 33/566 (86) International application number: PCT/US0105/750 (87) International publication number: WO 0106/2780 (30.08.2001 Gazette 2001/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.02.2000 US 184591 P (71) Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES La JollaCalifornia 92037 (US)	(72) Inventors: GAGE, Fred, H. La Jolla, CA 92037 (US) SUHR, Steven, T. La Jolla, CA 92037 (US) (74) Representative: Fiener, Josef et al Patentanwalt J. Fiener et col.P.O. Box 12 49 87712 Mindelheim 87712 Mindelheim (DE)