(19)

(11)

EP 1 259 600 A2

(12)

(88) Date of publication A3: 14.03.2002 (43) Date of publication: 27.11.2002 Bulletin 2002/48 (21) Application number: 01920209.2 (22) Date of filing: 02.03.2001

(51) International Patent Classification (IPC)7: C12N 15/09 (86) International application number: PCT/US0107/051 (87) International publication number: WO 0106/6717 (13.09.2001 Gazette 2001/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.03.2000 US 187220 P 13.03.2000 US 188672 P 28.12.2000 US 258682 P (71) Applicant: University of Utah Salt Lake City,Utah 84108 (US)	(72) Inventors: GOLIC, Kent, G. Salt Lake City, UT 84108 (US) RONG, Yikang, S. Salt Lake City, UT 84116 (US) DREWS, Gary, N. Salt Lake City, UT 84108 (US) (74) Representative: Fisher, Adrian John et al CARPMAELS & RANSFORD43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)