(19)
(11) EP 1 261 323 A2

(12)

(88) Date of publication A3:
18.04.2002

(43) Date of publication:
04.12.2002 Bulletin 2002/49

(21) Application number: 00989533.5

(22) Date of filing: 22.12.2000
(51) International Patent Classification (IPC)7A61K 31/00
(86) International application number:
PCT/US0035/439
(87) International publication number:
WO 0104/5691 (28.06.2001 Gazette 2001/26)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 22.12.1999 US 171710 P

(71) Applicant: Inspire Pharmaceuticals, Inc.
Durham, NC 27703 (US)

(72) Inventors:
  • YERXA, Benjamin, R.
    Raleigh, NC 27607 (US)
  • RIDEOUT, Janet, L.
    Raleigh, NC 27607-3010 (US)
  • PENDERGAST, William
    Durham, NC 27713 (US)
  • SHAVER, Sammy, R.
    Chapel Hill, NC 27516-9459 (US)
  • ZHANG, Zhen
    Apex, NC 27502 (US)
  • PETERSON, Ward, M.
    Durham, NC 27703 (US)
  • COWLEN, Mathew
    Chapel Hill, NC 27707 (US)

(74) Representative: Akers, Noel James et al
Howrey Simon Arnold & White,City Point,One Ropemaker Street
London EC2Y 9HS
London EC2Y 9HS (GB)

   


(54) METHOD OF TREATING GASTROINTESTINAL TRACT DISEASE WITH PURINERGIC RECEPTOR AGONISTS