(19)

(11)

EP 1 261 331 A1

(12)

(43) Date of publication: 04.12.2002 Bulletin 2002/49 (21) Application number: 01910707.7 (22) Date of filing: 15.02.2001

(51) International Patent Classification (IPC)7: A61K 31/275 (86) International application number: PCT/US0104/797 (87) International publication number: WO 0106/0358 (23.08.2001 Gazette 2001/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.02.2000 US 182876 P 24.08.2000 US 227629 P (71) Applicant: UNIVERSITY OF NEBRASKA MEDICAL CENTER Omaha, NE 68198 (US)	(72) Inventors: RENNARD, Steve, I. Omaha, NE 68198 (US) KOHYAMA, Tadashi Omaha, NE 68198 (US) (74) Representative: Walker, Ralph Francis, Dr.  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)