(19)

(11)

EP 1 261 354 A1

(12)

(43) Date of publication: 04.12.2002 Bulletin 2002/49 (21) Application number: 00904645.9 (22) Date of filing: 02.02.2000

(51) International Patent Classification (IPC)7: A61K 31/715, C12N 15/00, C12N 15/63, C12N 15/85 (86) International application number: PCT/US0002/628 (87) International publication number: WO 0004/5825 (10.08.2000 Gazette 2000/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.02.2000 US 495675 (71) Applicant: Safescience, Inc. Boston, MA 02116 (US)	(72) Inventors: PLATT, David Newton, MA 02159 (US) CHANG, Yan Chestnut Hill, MA 02467 (US) (74) Representative: Chapman, Paul Gilmour et al Cruikshank & Fairweather,19 Royal Exchange Square Glasgow G1 3AE Glasgow G1 3AE (GB)