(19)

(11)

EP 1 261 369 A2

(12)

(88) Date of publication A3: 24.01.2002 (43) Date of publication: 04.12.2002 Bulletin 2002/49 (21) Application number: 00957764.4 (22) Date of filing: 24.08.2000

(51) International Patent Classification (IPC)7: A61K 39/02, A61K 39/112 (86) International application number: PCT/US0023/242 (87) International publication number: WO 0102/5397 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.10.1999 US 157500 P 04.10.1999 US 157581 P 04.10.1999 US 157637 P (71) Applicant: Vion Pharmaceuticals, Inc. New Haven, CT 06511 (US)	(72) Inventors: BERMUDES, David, G. Wallingford, CT 06492 (US) KING, Ivan, C. New Haven, CT 06473 (US) CLAIRMONT, Caroline, A. Cheshire, CT 06410 (US) LIN, Stanley, L. Madison, CT 06443 (US) BELCOURT, Michael Wallingford, CT 06942 (US) (74) Representative: Stark, Amanda Jane et al Abel & Imray,20 Red Lion Street London WC1R 4PQ London WC1R 4PQ (GB)