(19)

(11)

EP 1 261 716 A2

(12)

(88) Date of publication A3: 26.09.2002 (43) Date of publication: 04.12.2002 Bulletin 2002/49 (21) Application number: 00980462.6 (22) Date of filing: 16.11.2000

(51) International Patent Classification (IPC)7: C12N 15/31, C12Q 1/68, C12Q 1/70, B01J 19/00, C07K 14/195 (86) International application number: PCT/US0031/579 (87) International publication number: WO 0103/6683 (25.05.2001 Gazette 2001/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.11.1999 US 165881 P 06.01.2000 US 479457 (71) Applicant: Apollo Biotechnology, Inc. Mountain View, CA 94043 (US)	(72) Inventor: LIU, Zhiping Mountain View, CA 94040 (US) (74) Representative: Sexton, Jane Helen  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)