(19)

(11)

EP 1 263 284 A1

(12)

(43) Date of publication: 11.12.2002 Bulletin 2002/50 (21) Application number: 00964449.3 (22) Date of filing: 29.09.2000

(51) International Patent Classification (IPC)7: A01K 67/027, C12N 15/12, C07K 14/47 (86) International application number: PCT/GB0003/747 (87) International publication number: WO 0102/4625 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.10.1999 GB 9923334 (71) Applicant: SmithKline Beecham plc Brentford,Middlesex TW8 9GS (GB)	(72) Inventors: ABUIN, Alejandro,SmithKLine Beecham Pharm. HarlowEssex CM19 5AW (GB) CLAPHAM, JohnSmithKline Beecham Pharmaceuticals HarlowEssex CM19 5AW (GB) (74) Representative: Connell, Anthony Christopher  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)