(19)

(11)

EP 1 263 427 A1

(12)

(43) Date of publication: 11.12.2002 Bulletin 2002/50 (21) Application number: 01924195.9 (22) Date of filing: 16.03.2001

(51) International Patent Classification (IPC)7: A61K 31/17, A61K 31/35, A61K 31/445, A61K 31/495, C07C 211/56, C07C 241/04, C07C 275/30, C07C 275/32, C07C 275/40, C07C 315/00 (86) International application number: PCT/US0108/672 (87) International publication number: WO 0106/8084 (20.09.2001 Gazette 2001/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.03.2000 US 189848 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: WIDDOWSON, Katherine, L. King of Prussia, PA 19406 (US) JIN, Qi King of Prussia, PA 19406 (US) (74) Representative: Quillin, Helen Kaye  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)