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(11)

EP 1 263 762 A1

(12)

(43) Date of publication: 11.12.2002 Bulletin 2002/50 (21) Application number: 01913190.3 (22) Date of filing: 27.02.2001

(51) International Patent Classification (IPC)7: C07D 501/00, A61K 31/545, A61K 31/546, A61P 31/04 (86) International application number: PCT/US0106/519 (87) International publication number: WO 0106/4687 (07.09.2001 Gazette 2001/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.02.2000 US 185479 P (71) Applicant: Newbiotics Inc. San Diego, California 92121 (US)

(72) Inventors: SHEPARD, H., Michael Encinitas, CA 92024 (US) CHAN, Ming, Fai Encinitas, CA 92024-5653 (US) DOPPALAPUDI, Venkata, Ramana San Diego, CA 92130 (US) CATHERS, Brian, Edwin San Diego, CA 92129 (US) HIXON, Mark, Stephen San Diego, CA 92126 (US) LOBL, Thomas, J. Foster City, CA 94404 (US) (74) Representative: Gates, Marie Christina Esther et al c/o Tomkins & Co.5 Dartmouth Road Dublin 6 Dublin 6 (IE)