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EP 1 263 765 A1

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(43) Date of publication: 11.12.2002 Bulletin 2002/50 (21) Application number: 00919726.0 (22) Date of filing: 28.03.2000

(51) International Patent Classification (IPC)7: C07H 21/02, C07H 21/04, C12Q 1/68, A01N 43/04, A61K 31/70, C12N 15/85, C12N 15/86 (86) International application number: PCT/US0008/174 (87) International publication number: WO 0107/2765 (04.10.2001 Gazette 2001/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (71) Applicant: ISIS PHARMACEUTICALS, INC. Carlsbad, CA 92008 (US)

(72) Inventors: BENNETT, C., Frank Carlsbad, CA 92008 (US) CROOKE, Stanley, T. Carlsbad, CA 92009 (US) MANOHARAN, Muthiah Carlsbad, CA 92009 (US) WYATT, Jacqueline, R. Encinitas, CA 92024 (US) BAKER, Brenda, F. Carlsbad, CA 92009 (US) MONIA, Brett, P. La Costa, CA 92009 (US) FREIER, Susan, M. San Diego, CA 92122 (US) McKAY, Robert San Diego, CA 92116 (US) KARRAS, James, G. San Marcos, CA 92069 (US) (74) Representative: Hallybone, Huw George et al Carpmaels and Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)