(19)

(11)

EP 1 263 955 A2

(12)

(88) Date of publication A3: 20.06.2002 (43) Date of publication: 11.12.2002 Bulletin 2002/50 (21) Application number: 01916558.8 (22) Date of filing: 12.03.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/10, C12N 15/66, C07K 14/47, C07K 16/18, G01N 33/53, G01N 33/68, C12Q 1/68, A61K 38/17, A61K 39/395, A61K 31/70 (86) International application number: PCT/US0107/735 (87) International publication number: WO 0106/8851 (20.09.2001 Gazette 2001/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.03.2000 US 188316 P 10.03.2000 US 188277 P 14.03.2000 US 189139 P 14.03.2000 US 189140 P 17.03.2000 US 190401 P 17.03.2000 US 190231 P (71) Applicant: Curagen Corporation New Haven, CT 06511 (US)

(72) Inventors: PADIGARU, Muralidhara Bronx, NY 10561 (US) VERNET, Corine, A., M. North Branford, CT 06471 (US) FERNANDES, Elma Branford, CT 06405 (US) SHIMKETS, Richard, A. West Haven, CT 06516 (US) SPADERNA, Steven, K. Berlin, CT 06037 (US) MAJUMDER, Kumud Stamford, CT 06905 (US) LI, Li Chesire, CT 06410 (US) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)