(19)

(11)

EP 1 265 634 A1

(12)

(43) Date of publication: 18.12.2002 Bulletin 2002/51 (21) Application number: 01918368.0 (22) Date of filing: 06.03.2001

(51) International Patent Classification (IPC)7: A61K 39/395, C12P 19/34, C07K 16/00 (86) International application number: PCT/US0107/069 (87) International publication number: WO 0106/8130 (20.09.2001 Gazette 2001/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.03.2000 US 525043 (71) Applicant: National Jewish Medical and Research Center Denver, CO 80206 (US)	(72) Inventors: GELFAND, Erwin, W. Englewood, CO 80110 (US) MÄKELA, Mika Denver, CO 80246 (US) (74) Representative: Evens, Paul Jonathan et al Maguire Boss,5 Crown Street St. Ives,Cambridge PE27 5EB St. Ives,Cambridge PE27 5EB (GB)