(19)

(11)

EP 1 265 854 A1

(12)

(43) Date of publication: 18.12.2002 Bulletin 2002/51 (21) Application number: 01911986.6 (22) Date of filing: 20.03.2001

(51) International Patent Classification (IPC)7: C07C 271/68, C07C 47/225, A61K 31/11, A61K 31/325 (86) International application number: PCT/GB0101/213 (87) International publication number: WO 0107/0676 (27.09.2001 Gazette 2001/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.03.2000 GB 0006741 (71) Applicant: PHARMA MAR, S.A. 28760 Tres Cantos,Madrid (ES)	(72) Inventors: TANAKA, JunichiUniversity of the Ryukyus Okinawa 903-0213 (JP) HIGA, TatsuoUniversity of the Ryukyus Okinawa 903-0213 (JP) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)