(19)

(11)

EP 1 267 878 A2

(12)

(88) Date of publication A3: 25.04.2002 (43) Date of publication: 02.01.2003 Bulletin 2003/01 (21) Application number: 01914447.6 (22) Date of filing: 23.02.2001

(51) International Patent Classification (IPC)7: A61K 31/506, A61P 27/06 (86) International application number: PCT/US0105/740 (87) International publication number: WO 0107/0230 (27.09.2001 Gazette 2001/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 17.03.2000 US 190279 P (71) Applicant: Alcon, Inc 6331 Hünenberg (CH)	(72) Inventors: COLLIER, Robert, J., Jr. Arlington, TX 76016 (US) HELLBERG, Mark, R. Arlington, TX 76017 (US) DEAN, Thomas, R. Weatherford, TX 76087 (US) (74) Representative: Teipel, Stephan, Dr.  Lederer & KellerPatentanwältePrinzregentenstrasse 16 80538 München 80538 München (DE)