(19)
(11) EP 1 267 913 A2

(12)

(88) Date of publication A3:
12.09.2002

(43) Date of publication:
02.01.2003 Bulletin 2003/01

(21) Application number: 00982091.1

(22) Date of filing: 10.11.2000
(51) International Patent Classification (IPC)7A61K 38/39, A61K 31/675, A61K 31/505, A61P 35/00
(86) International application number:
PCT/US0030/742
(87) International publication number:
WO 0103/4174 (17.05.2001 Gazette 2001/20)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 12.11.1999 US 439901
03.04.2000 US 194150 P

(71) Applicants:
  • EntreMed, Inc.
    Rockville, MD 20850 (US)
  • The Children's Medical Center Corporation
    Boston, Massachusetts 02115 (US)

(72) Inventors:
  • SIM, Kim, Lee
    Gaithersburg, MD 20878 (US)
  • KISKER, Oliver
    Newton, MA 02464 (US)
  • FOGLER, Willilam, E.
    Rockville, MD 20850 (US)
  • BROWDER, Timothy
    Chestnut Hill, MA 02467 (US)
  • O'REILLY, Michael, S.
    Winchester, MA 01890 (US)
  • FOLKMAN, M., Judah
    Brookline, MA 02146 (US)

(74) Representative: Stevens, Ian Edward 
Eric Potter Clarkson,Park View House,58 The Ropewalk
Nottingham NG1 5DD
Nottingham NG1 5DD (GB)

   


(54) METHODS FOR ADMINISTRATION OF THERAPEUTIC AGENTS ON AN ANTIANGIOGENIC SCHEDULE