(19)

(11)

EP 1 268 520 A2

(12)

(88) Date of publication A3: 14.03.2002 (43) Date of publication: 02.01.2003 Bulletin 2003/01 (21) Application number: 01920643.2 (22) Date of filing: 21.03.2001

(51) International Patent Classification (IPC)7: C07K 7/00, C07K 14/705, A61K 38/08, A61P 31/18, G01N 33/566, G01N 33/68 (86) International application number: PCT/US0109/160 (87) International publication number: WO 0107/0768 (27.09.2001 Gazette 2001/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.03.2000 US 190946 P 21.03.2000 US 190996 P 21.03.2000 US 191299 P 20.03.2001 US 813651 20.03.2001 US 813653 20.03.2001 US 813448 (71) Applicant: Consensus Pharmaceuticals, Inc. Medford, MA 02155 (US)	(72) Inventors: NESTOR, John, J., Jr. Bedford, MA 01730 (US) WILSON, Carol, J. Somerville, MA 02145 (US) TAN HEHIR, Christina, A. Arlington, MA 02474 (US) KATES, Steven, A. Needham, MA 02494 (US) (74) Representative: Muir, Justine Claire  Graham Watt & Co.7-9 St. Botolph's Road Sevenoaks, Kent TN13 3AJ Sevenoaks, Kent TN13 3AJ (GB)