(19)

(11)

EP 1 268 541 A1

(12)

(43) Date of publication: 02.01.2003 Bulletin 2003/01 (21) Application number: 01926376.3 (22) Date of filing: 16.03.2001

(51) International Patent Classification (IPC)7: C07K 14/47, C12N 5/10, C12N 5/16, C12N 15/12, C12N 15/63, C12N 15/64 (86) International application number: PCT/US0108/585 (87) International publication number: WO 0107/0804 (27.09.2001 Gazette 2001/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.03.2000 US 190076 P 23.08.2000 US 227009 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: BIRSE, Charles, E. North Potomac, MD 20878 (US) ROSEN, Craig, A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)