(19)

(11)

EP 1 268 788 A2

(12)

(88) Date of publication A3: 16.05.2002 (43) Date of publication: 02.01.2003 Bulletin 2003/01 (21) Application number: 01922729.7 (22) Date of filing: 27.03.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 9/00, C12N 5/10 (86) International application number: PCT/US0109/775 (87) International publication number: WO 0107/2978 (04.10.2001 Gazette 2001/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.03.2000 US 192226 P (71) Applicant: Washington State University Research Foundation Pullman, WA 99164-1802 (US)	(72) Inventors: KASAHARA, Hiroyuki Wako-Shi,Saitama 351-0112 (JP) DAVIN, Laurence, B. Pullman, WA 99163 (US) LEWIS, Norman, G. Pullman, WA 99163 (US) (74) Representative: Ford, Timothy James et al Kilburn & Strode20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)